| 1400W | Drosophila melanogaster | | | 13.0 | 24096697 |
| 17-A-Estradiol | Mice | | 12.0 | 0.0 | 24245565 |
| 2-(2-Aminophenyl)-1H-Benzimidazole | Caenorhabiditis elegans | | 35.0 | | 21451522 |
| 2-(2-Hydroxyphenyl) Benzothiazole (Hbt) | Caenorhabiditis elegans | | 23.0 | | 21451522 |
| 2-(2-Hydroxyphenyl)-Benzoxazole | Caenorhabiditis elegans | | 40.0 | | 21451522 |
| 2-Deoxy-D-Glucose | Rat | | | -10.0 | |
| Acarbose | Mice | | 22.0 | 11.0 | 24245565 |
| Acetaminophen | Caenorhabiditis elegans | | | 66.0 | 22114686 |
| Aspirin | Mice | | 8.0 | | 18631321 |
| Bacitracin | Caenorhabiditis elegans | | | 74.0 | 22114686 |
| Baicalein | Caenorhabiditis elegans | | | 52.0 | 22114686 |
| Beauveriolide I | Saccharomyces cerevisiae | | | | 22790951 |
| Buformin | Caenorhabiditis elegans | | 23.5 | 26.1 | Bakaev VV (2002. Effect of 1-butylbiguanide hydrochloride on the longevity in the nematoda Caenorhabditis elegans. Biogerontology 3 (Suppl 1): 23–24 |
| Butein | Saccharomyces cerevisiae | | | | 12939617 |
| CaEDTA | Caenorhabiditis elegans | | 23.39 | 12.49 | 25554795 |
| Caffeine | Schizosaccharomyces pombe | | | | 23551936 |
| Caffeine | Saccharomyces cerevisiae | | | | 18513215 |
| Caffeine | Saccharomyces cerevisiae | | | | 24039592 |
| Caffeine | Caenorhabditis elegans | | 29.4 | 52.0 | 22114686 |
| Carbonyl Cyanide M-Chlorophenyl Hydrazone | Caenorhabditis elegans | | 60.0 | | 19442682 |
| Chloramphenicol | Caenorhabditis elegans | | 17.0 | | 23698443 |
| Chromium Picolinate | Rat | | | 36.0 | Evans GW, Meyers IK (1994) Life span is increased in rats supplemented with chromium -pyridine 2-carboxylate complex. Adv In Sci Res 1, 19-23 |
| Ciclopirox Olamine | Caenorhabditis elegans | | | 52.0 | 22114686 |
| Creatine | Mice | | 9.0 | | 17416441 |
| D-Chiro-Inositol | Drosophila melanogaster | | 16.7 | | 22843669 |
