Beauveriolide I

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CAS: 154491-55-1

Name:

Beauveriolide I

Other names:

(3R,6S,9S,13S)-9-Benzyl-13-[(2S)-2-hexanyl]-3-isobutyl-6-methyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

The depsipeptide from the fungal strain Beauveria sp. FO-6979. It has been shown that Beauveriolide I reduce atherogenic lesions in mouse models of atherosclerosis, and has potential ß-amyloid lowering activity [PMID:19396893]

Interactions

No targets available

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Amiloid
Anti Atherogenic
Anti Obesity
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Beta-amyloid-lowering compound

19396893

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
50.0
Cell RLS

Concentration wth maximum effect

20 mg/ml

More info about experiment

22790951
Opposite effectNo