Warning! Toxic compound!

Carbonyl Cyanide M-Chlorophenyl Hydrazone

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CAS: 555-60-2

Name:

Carbonyl Cyanide M-Chlorophenyl Hydrazone

Other names:

CCCP; (3-Chlorophenyl)hydrazonomalononitrile; Carbonylcyanide-3-chlorophenylhydrazone

A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. Carbonyl Cyanide m-Chlorophenylhydrazone, a protonophore and an inhibitor of ER-Golgi protein transport, has been reported to bind to Cytochrome C oxidase with a high affinity. In experiments done on bullfrog sympathetic ganglia, this compound increased spontaneous release of luteinizing hormone-releasing hormone, which strongly depended on firing frequency. Other studies suggest that Carbonyl Cyanide m-Chlorophenylhydrazone is also a proton conductor that could greatly affect E.coli cell viability in the presence of glucose.

Interactions

Description

UniProt ID

Gene: COX4I1
Protein: Cytochrome c oxidase subunit 4 isoform 2, mitochondrial, Gene: COX4I2
Protein: Cytochrome c oxidase subunit 5A, mitochondrial, Gene: COX5A
Protein: Cytochrome c oxidase subunit 5B, mitochondrial, Gene: COX5B
Protein: Cytochrome c oxidase subunit 6A1, mitochondrial, Gene: COX6A1
Protein: Cytochrome c oxidase subunit 6A2, mitochondrial, Gene: COX6A2
Protein: Cytochrome c oxidase subunit 6B1, Gene: COX6B1
Protein: Cytochrome c oxidase subunit 6B2, Gene: COX6B2
Protein: Cytochrome c oxidase subunit 6C, Gene: COX6C
Gene: COX7A1
Protein: Cytochrome c oxidase subunit 7A2, mitochondrial, Gene: COX7A2
Protein: Cytochrome c oxidase subunit 7B, mitochondrial, Gene: COX7B
Protein: Cytochrome c oxidase subunit 7B2, mitochondrial, Gene: COX7B2
Protein: Cytochrome c oxidase subunit 7C, mitochondrial, Gene: COX7C
Protein: Cytochrome c oxidase subunit 8A, mitochondrial, Gene: COX8A
Protein: Cytochrome c oxidase subunit 8C, mitochondrial, Gene: COX8C
Gene: SLC18A1

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

No data
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
Median LS (%)
60.0
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

15 mkM

More info about experiment

19442682
Opposite effectNo