Warning! Toxic compound!
Carbonyl Cyanide M-Chlorophenyl Hydrazone
CAS: 555-60-2
Name:
Carbonyl Cyanide M-Chlorophenyl Hydrazone
Other names:
CCCP; (3-Chlorophenyl)hydrazonomalononitrile; Carbonylcyanide-3-chlorophenylhydrazone
A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. Carbonyl Cyanide m-Chlorophenylhydrazone, a protonophore and an inhibitor of ER-Golgi protein transport, has been reported to bind to Cytochrome C oxidase with a high affinity. In experiments done on bullfrog sympathetic ganglia, this compound increased spontaneous release of luteinizing hormone-releasing hormone, which strongly depended on firing frequency. Other studies suggest that Carbonyl Cyanide m-Chlorophenylhydrazone is also a proton conductor that could greatly affect E.coli cell viability in the presence of glucose.
Interactions
Description
UniProt ID
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataNo
No
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
Experimental conditions
Agar nematode growth medium + E. coli OP50Life Extension
- Mean LS (%)
- —
- Median LS (%)
- 60.0
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
15 mkM