1400W
CAS: 214358-33-5
Name:
1400W
Other names:
N-(3-Aminomethyl)benzylacetamidine; 14W; Bio1_001405; Tocris-1415; SureCN4467; AC1L1BGT; AC1Q4SXP; N-([3-(Aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride
A slow, tight binding and highly selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II) in vitro and in vivo. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices.
Interactions
Description
UniProt ID
Protein: Nanos homolog 3, Gene: NANOS3
Protein: Nitric oxide synthase, inducible, Gene: NOS2
Protein: Nanos homolog 1, Gene: NANOS1
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataAntibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelDrosophila melanogaster
SrainCanton-S
SexMale
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- 13.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0.03 mkM
More info about experiment
Opposite effectNo
Model organism
ModelDrosophila melanogaster
SrainCanton-S
SexMale
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 7.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
3 mkM
More info about experiment
Opposite effectNo