Caffeine

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CAS: 58-08-2

Name:

Caffeine

Other names:

1,3,7-Trimethylxanthine

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine’s most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide phosphodiesterases, antagonism of adenosine receptors, and modulation of intracellular calcium handling.

Interactions

Description

UniProt ID

Protein: Group 10 secretory phospholipase A2, Gene: PLA2G10
Protein: Group XIIA secretory phospholipase A2, Gene: PLA2G12A
Protein: Group XIIB secretory phospholipase A2-like protein, Gene: PLA2G12B
Protein: Phospholipase A(2), Gene: PLA2G1B
Protein: Phospholipase A2, membrane associated, Gene: PLA2G2A
Protein: Group IID secretory phospholipase A2, Gene: PLA2G2D
Protein: Group IIE secretory phospholipase A2, Gene: PLA2G2E
Protein: Group IIF secretory phospholipase A2, Gene: PLA2G2F
Protein: Group 3 secretory phospholipase A2, Gene: PLA2G3
Protein: Cytosolic phospholipase A2, Gene: PLA2G4A
Protein: Cytosolic phospholipase A2 gamma, Gene: PLA2G4C
Protein: Calcium-dependent phospholipase A2, Gene: PLA2G5
Protein: 85/88 kDa calcium-independent phospholipase A2, Gene: PLA2G6
Protein: Platelet-activating factor acetylhydrolase, Gene: PLA2G7
Protein: Calcium-independent phospholipase A2-gamma, Gene: PNPLA8
Protein: Peroxiredoxin-6, Gene: PRDX6
Protein: Adenosine receptor A1, Gene: ADORA1
Protein: Putative uncharacterized protein ADORA2A-AS1, Gene: ADORA2A-AS1
Protein: Adenosine receptor A2b, Gene: ADORA2B
Protein: Serine-protein kinase ATM, Gene: ATM
Gene: ADORA3
Protein: Serine/threonine-protein kinase ATR, Gene: ATR
Gene: CHIA
Protein: Chitotriosidase-1, Gene: CHIT1
Protein: Sodium/nucleoside cotransporter 1, Gene: SLC28A1
Protein: Sodium/nucleoside cotransporter 2, Gene: SLC28A2
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Potassium voltage-gated channel subfamily H member 6, Gene: KCNH6
Gene: ITPR1
Protein: Potassium voltage-gated channel subfamily H member 2, Gene: KCNH2
Protein: Potassium voltage-gated channel subfamily H member 7, Gene: KCNH7
Protein: Sodium/hydrogen exchanger 3, Gene: SLC9A3
Protein: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Gene: PDE1A
Protein: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Gene: PDE1B
Protein: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, Gene: PDE1C
Protein: cAMP-specific 3',5'-cyclic phosphodiesterase 4A, Gene: PDE4A
Protein: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, Gene: PDE4B
Protein: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Gene: PIK3CA
Gene: PIK3CB
Protein: Putative uncharacterized protein PIK3CD-AS1, Gene: PIK3CD-AS1
Protein: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Gene: PIK3CG
Protein: Glycogen phosphorylase, brain form, Gene: PYGB
Protein: Glycogen phosphorylase, liver form, Gene: PYGL
Protein: Glycogen phosphorylase, muscle form, Gene: PYGM
Gene: EPHA4
Protein: Potassium voltage-gated channel subfamily D member 2, Gene: KCND2

Toxicity

oral LD50 [mouse] mg/kg
> 127.0
oral LD50 [rat] mg/kg
> 192.0
oral LD50 [rabbit] mg/kg
> 224.0

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Anti Obesity
Neuroprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

PIK3CAPIK3CBATMATR

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
0.0
Cell RLS

Concentration wth maximum effect

10 mM

More info about experiment

23551936
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
0.0
Cell RLS

Concentration wth maximum effect

0,2-0,4 mM

More info about experiment

18513215
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

More info about experiment

24039592
Opposite effectNo

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
Median LS (%)
29.4
Mortality rate derease (%)
53.0
Max LS (%)
52.0
Cell CLS
Cell RLS

Concentration wth maximum effect

0.1% (5.15 mM)

More info about experiment

22114686
Opposite effectNo