Caffeine
CAS: 58-08-2
Name:
Caffeine
Other names:
1,3,7-Trimethylxanthine
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine’s most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide phosphodiesterases, antagonism of adenosine receptors, and modulation of intracellular calcium handling.
Interactions
Description
UniProt ID
Toxicity
- oral LD50 [mouse] mg/kg
- > 127.0
- oral LD50 [rat] mg/kg
- > 192.0
- oral LD50 [rabbit] mg/kg
- > 224.0
Effects on organism
No
No
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Model organism
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- 0.0
- Cell RLS
- —
Concentration wth maximum effect
10 mM
More info about experiment
Model organism
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- 0.0
- Cell RLS
- —
Concentration wth maximum effect
0,2-0,4 mM
More info about experiment
Model organism
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
More info about experiment
Model organism
Experimental conditions
Agar nematode growth medium + E. coli OP50Life Extension
- Mean LS (%)
- —
- Median LS (%)
- 29.4
- Mortality rate derease (%)
- 53.0
- Max LS (%)
- 52.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0.1% (5.15 mM)