Buformin
CAS: 692-13-7
Name:
Buformin
Other names:
1-Butylbiguanide; Buformine; Butylbiguanide; Butylbiguanidum; Butyldiguanide; Butformin; Glybigid; Glybigidum; Adebit
Buformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of causing lactic acidosis.
Interactions
Description
UniProt ID
Protein: Glutathione-specific gamma-glutamylcyclotransferase 1, Gene: CHAC1
Protein: Solute carrier family 22 member 2, Gene: SLC22A2
Protein: Tumor necrosis factor receptor superfamily member 1A, Gene: TNFRSF1A
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- 23.5
- Mortality rate derease (%)
- —
- Max LS (%)
- 26.1
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
More info about experiment
Opposite effectNo
Model organism
ModelRat
SrainLIO
SexFemale
Age of treatment3,5 months
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 7.3
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- 5.5
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
5 mg/rat/day
More info about experiment
Opposite effectNo