Aspirin
CAS: 50-78-2
Name:
Aspirin
Other names:
ACETYLSALICYLIC ACID; 2-Acetoxybenzoic acid; Ecotrin; Acenterine; Acylpyrin; Polopiryna; Easprin; Acetylsalicylate; Colfarit
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Interactions
Description
UniProt ID
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 200.0
- oral LD50 [rabbit] mg/kg
- Unavailable
No
No
No
Longevity mechanisms activation
Suppression of aging mechanisms
Relation to biomarkers of Aging
For example, aspirin has beneficial anti-inflammatory and antithrombotic properties and can slightly extend lifespan in male, but not female, mice. Human epidemiological studies suggest its long-term use can reduce the risk of certain types of cancer and cardiovascular disease , yet it also increases risk of gastrointestinal bleeding .
Model organism
Experimental conditions
Agar nematode growth medium + E. coli OP50Life Extension
- Mean LS (%)
- 23.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,5-1 mM
More info about experiment
Model organism
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- 8.0
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
20-60 mg/kg