17-A-Estradiol

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CAS: 57-91-0

Name:

17-A-Estradiol

Other names:

Epiestradiol; alpha-Estradiol; 17alpha-Estradiol; Estradiol-17alpha; 3,17-Dihydroxyestratriene; 17-alpha-Estradiol; Epiestradial; Alfatradiol

α-Estradiol is an endogenous ligand for estrogen receptors ERα (Ki = 0.2 nM) and ERβ (Ki = 1.2 nM). Studies indicate that α-Estradiol is a short acting estrogen which only forms complexes with estrogen ligand receptors for a short period of time. These studies suggest that α-estradiol is beneficial in studying the affects caused by the MAPK signaling cascade such as cell division, neuronal differentiation, and neuronal survival in the developing brain. Furthermore, α-estradiol inhibits the influx of calcium in human aortic smooth muscle cells.

Interactions

No targets available

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Atherogenic
Neuroprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Skin aging can be significantly delayed by the administration of estrogen

18044179

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
12.0
Mortality rate derease (%)
Max LS (%)
0.0
Cell CLS
Cell RLS

Concentration wth maximum effect

4,8 mg/kg diet

More info about experiment

24245565
Opposite effectNo