Acarbose

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CAS: 56180-94-0

Name:

Acarbose

Other names:

ACA; Bay g 5421; Glucobay; Precose; EINECS 260-030-7; Precose (TN)

An inhibitor of alpha glucosidase that retards the digestion and absorption of carbohydrates in the small intestine and hence reduces the increase in blood-glucose concentrations after a carbohydrate load. It is given orally to non-insulin dependent diabetes mellitus patients where diet modification or oral hypoglycemic agents do not control their condition [DrugBank].

Interactions

Description

UniProt ID

Protein: Maltase-glucoamylase, intestinal, Gene: MGAM
Protein: Citrate synthase, mitochondrial, Gene: CS

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Obesity
Anti Diabetic
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Reduces blood glucose concentrations

23093911

Relation to aging associated genes

TERT

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
22.0
Mortality rate derease (%)
Max LS (%)
11.0
Cell CLS
Cell RLS

Concentration wth maximum effect

1000 mg/kg diet

More info about experiment

24245565
Opposite effectNo