Chloramphenicol

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CAS: 56-75-7

Name:

Chloramphenicol

Other names:

Chlornitromycin; Chloromycetin; Chlorocid; Levomycetin; Globenicol; Halomycetin; Fenicol; Levomicetina; Chloramex

An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)

Interactions

No targets available

Toxicity

oral LD50 [mouse] mg/kg
> 1500.0
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Cardioprotective
Antibacterial

S1677

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

Inhibitors Of Protein Biosynthesis

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
17.0
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

100 mg/ml

More info about experiment

23698443
Opposite effectNo