Chloramphenicol
CAS: 56-75-7
Name:
Chloramphenicol
Other names:
Chlornitromycin; Chloromycetin; Chlorocid; Levomycetin; Globenicol; Halomycetin; Fenicol; Levomicetina; Chloramex
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- > 1500.0
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Cardioprotective
Antibacterial
S1677
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
Suppression of aging mechanisms
Inhibitors Of Protein Biosynthesis
Relation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- 17.0
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
100 mg/ml
More info about experiment
Opposite effectNo