Our database contains information about more than 250 experiments involving over 200 substances which have a geroprotective effect – from candidates to confirmed geroprotectors. Terms and keywords relevant to pharmacological interventions in ageing were used in a search of the PubMed database (http://www.ncbi.nlm.nih.gov/pubmed). We included papers comprising clear information about the model organism used, the tested substance, the experimental conditions, the age of subjects that were treated and any results. All entries are linked to the original work, making access to the raw data fast and convenient.
For descriptions of compounds and their effects on model organisms, we have used many sources with information about chemical and biological information. All substances have descriptions including data on their toxicity, clinical use, clinical trials (actual data), biological and pharmacological activities, interactions and so on.
We have divided the data about the various substances into 3 blocks. The first block contains an image, the name of the substance, a short description and links to other chemical databases. In addition, this block includes information about the number of clinical trials performed and the current status of drug development. The second block includes information about biological, pharmacological, toxicity and longevity mechanisms. The third block describes the compound’s associations with age-related pathologies (chronic inflammation, cancer, amyloid aggregation and so on).
(1) аliases, (2) statuses, (3) number of clinical trials, (4) antibacterial, antifungal or antiviral activity, (5) targets, (6)&(8) toxicology data, (7) side effects