Trametinib

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CAS: 871700-17-3

Name:

Trametinib

Other names:

Trametinib; GSK1120212; GSK 1120212; JTP 74057; JTP-74057

ChemSpider

DrugBank

ChEMBL

ChEBI

PubChem

Drug Status

Approved

Clinical trials

104 Studies

Interactions

No targets available

Related pathways

No information yet

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
25684183
Anti Cancer
25855137
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Model organism

ModelDrosophila melanogaster
SrainwDahomey
Sex—
Age of treatment—

Experimental conditions

Not available

Life Extension

Mean LS (%)
—
Median LS (%)
12.0
Mortality rate derease (%)
—
Max LS (%)
—
Cell CLS
—
Cell RLS
—

Concentration wth maximum effect

15.6 mM

More info about experiment

26119340 http://www.cell.com/cell/abstract/S0092-8674(15)00707-2
Opposite effectNo

Model organism

ModelDrosophila melanogaster
SrainwDahomey
Sex—
Age of treatment—

Experimental conditions

Not available

Life Extension

Mean LS (%)
—
Median LS (%)
8.0
Mortality rate derease (%)
—
Max LS (%)
—
Cell CLS
—
Cell RLS
—

Concentration wth maximum effect

1.56 mM

More info about experiment

26119340 http://www.cell.com/cell/abstract/S0092-8674(15)00707-2
Opposite effectNo