Vinpocetine

Imageshandler

CAS: 42971-09-5

Name:

Vinpocetine

Other names:

Cavinton; TCV-3B; Ethyl (+)-apovincaminate; Ethyl apovincamin-22-oate; Apovincaminic acid ethyl ester

Vinpocetine is a synthetic derivative of the minor alkaloid vincarmine from the Vinca genus of plants. This compound is a cyclic nucleotide PDE (Ca2+-depended/calmodulin-stimulated phosphodiesterase) inhibitor. Studies suggest that vinpocetine’s selective inhibition of PDE1 may induce vascular relaxation by increasing cyclic GMP contents in vascular smooth muscle.

Interactions

Description

UniProt ID

Protein: Sodium channel protein type 8 subunit alpha, Gene: SCN8A
Protein: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Gene: PDE1A
Protein: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Gene: PDE1B
Protein: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, Gene: PDE1C
Gene: SCN5A

Toxicity

oral LD50 [mouse] mg/kg
> 534.0
oral LD50 [rat] mg/kg
> 503.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Convulsant
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
15.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo