Vinpocetine
CAS: 42971-09-5
Name:
Vinpocetine
Other names:
Cavinton; TCV-3B; Ethyl (+)-apovincaminate; Ethyl apovincamin-22-oate; Apovincaminic acid ethyl ester
Vinpocetine is a synthetic derivative of the minor alkaloid vincarmine from the Vinca genus of plants. This compound is a cyclic nucleotide PDE (Ca2+-depended/calmodulin-stimulated phosphodiesterase) inhibitor. Studies suggest that vinpocetine’s selective inhibition of PDE1 may induce vascular relaxation by increasing cyclic GMP contents in vascular smooth muscle.
Interactions
Description
UniProt ID
Protein: Sodium channel protein type 8 subunit alpha, Gene: SCN8A
Protein: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Gene: PDE1A
Protein: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Gene: PDE1B
Protein: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, Gene: PDE1C
Gene: SCN5A
Toxicity
- oral LD50 [mouse] mg/kg
- > 534.0
- oral LD50 [rat] mg/kg
- > 503.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Convulsant
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 15.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo