Warning! Toxic compound!

Tyrphostin Ag 490

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CAS: 133550-30-8

Name:

Tyrphostin Ag 490

Other names:

Tyrphostin B42; AG-490; AG 490; Tyrphostin AG490; AG490

Tyrphostin AG 490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, Tyrphostin AG 490 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, Tyrphostin AG 490 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that Tyrphostin AG 490 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by Tyrphostin AG 490 leads to lower levels of p85 phosphorylation and p-13 kinase activation.

Interactions

Description

UniProt ID

Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Protein: Equilibrative nucleoside transporter 1, Gene: SLC29A1
Protein: G protein-regulated inducer of neurite outgrowth 1, Gene: GPRIN1
Protein: Glutamate receptor ionotropic, NMDA 2A, Gene: GRIN2A
Protein: Glutamate receptor ionotropic, NMDA 2B, Gene: GRIN2B
Protein: Glutamate receptor ionotropic, NMDA 2C, Gene: GRIN2C
Protein: Platelet-derived growth factor receptor alpha, Gene: PDGFRA
Protein: Platelet-derived growth factor receptor alpha, Gene: PDGFRA
Protein: Cyclin-dependent kinase 2, Gene: CDK2
Protein: Tyrosine-protein kinase JAK2, Gene: JAK2
Protein: Tyrosine-protein kinase JAK3, Gene: JAK3

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Atherogenic
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

PDGFRAPDGFRAJAK2

Experimental conditions

Not available

Life Extension

Mean LS (%)
17.5
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

300 mkM

More info about experiment

22363408
Opposite effectNo