Tyrphostin 9

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CAS: 10537-47-0

Name:

Tyrphostin 9

Other names:

Malonoben; Tyrphostin-9; GCP 5126; ENT 27910; Malonoben [ANSI]; NSC 242557; Caswell No. 291AA; Gulf S-15126

Tyrphostin 9 is a synthetic inhibitor of protein tyrosine kinase (PTK) that displays characteristics of a potent reversible inhibitor of platelet-derived growth factor (PDGF)-induced mitogenesis via inhibition of tyrosine kinase activity of the PDGFR (PDGF receptor) and other signaling cascades. These studies suggest that Tyrphostin 9 could potentially be used to inhibit cell proliferations which depend on protein tyrosine kinase for replication. This compound was also reported to inhibit actin ring formation and bone resorption in murine osteoclasts. Tyrphostin A9 is a calcium channel protein inhibitor of Calcium Channel Protein (calcium release-activated calcium (CRAC) channels)

Interactions

No targets available

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 87.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Cancer
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
17.3
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

300-500 mkM

More info about experiment

22363408
Opposite effectNo