Tyrphostin 9
CAS: 10537-47-0
Name:
Tyrphostin 9
Other names:
Malonoben; Tyrphostin-9; GCP 5126; ENT 27910; Malonoben [ANSI]; NSC 242557; Caswell No. 291AA; Gulf S-15126
Tyrphostin 9 is a synthetic inhibitor of protein tyrosine kinase (PTK) that displays characteristics of a potent reversible inhibitor of platelet-derived growth factor (PDGF)-induced mitogenesis via inhibition of tyrosine kinase activity of the PDGFR (PDGF receptor) and other signaling cascades. These studies suggest that Tyrphostin 9 could potentially be used to inhibit cell proliferations which depend on protein tyrosine kinase for replication. This compound was also reported to inhibit actin ring formation and bone resorption in murine osteoclasts. Tyrphostin A9 is a calcium channel protein inhibitor of Calcium Channel Protein (calcium release-activated calcium (CRAC) channels)
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 87.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No
No
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 17.3
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
300-500 mkM