Trichostatin A

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CAS: 58880-19-6

Name:

Trichostatin A

Other names:

TSA; Trichostatin A (TSA); TSA, Trichostatin A

Trichostatin A (TSA) is a potent and non-competitive reversible inhibitor of histone deacetylases (HDAC) with a Ki of 3.4 nM. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In cells latently infected with HIV-1, TSA induced the transcriptional activation of the HIV-1 promoter, which resulted in a marked increase in virus production. In NIH 3T3 cells, TSA induced reversion of oncogenic ras-transformed cells to a normal morphology. In Jurkat cells, TSA inhibited IL-2 gene expression and displayed immunosuppressive activity in a mouse model. Induces increased acetylation of GATA4, a cardiac-specific transcription factor and increases cardiac muscle cell differentiation. In normal fibroblasts, induced Friend cell differentiation and inhibited the G1 and G2 phases of the cell cycle. Trichostatin A is a useful tool for induction of hyperacetylation of cellular histones and for further elucidation of their role in gene expression. A glucoside analog of Trichostatin A is also offered as Trichostatin C (sc-202369). Trichostatin A is an inhibitor of TERT, HDAC1, HDAC4 and HDAC6.

Interactions

Description

UniProt ID

Gene: NR1I3
Protein: Caspase-3, Gene: CASP3
Protein: Caspase-9, Gene: CASP9
Protein: Histone deacetylase, Gene: HDAC1
Protein: Histone deacetylase 2, Gene: HDAC2
Gene: HDAC10
Protein: F-box-like/WD repeat-containing protein TBL1XR1, Gene: TBL1XR1
Protein: Histone deacetylase 4, Gene: HDAC4
Protein: Histone deacetylase 5, Gene: HDAC5
Protein: Histone deacetylase 6, Gene: HDAC6
Protein: Histone deacetylase 7, Gene: HDAC7
Protein: Histone deacetylase 8, Gene: HDAC8
Protein: Histone deacetylase 9, Gene: HDAC9
Protein: Interleukin-17A, Gene: IL17A
Protein: Histone-binding protein RBBP4, Gene: RBBP4
Protein: Histone-binding protein RBBP7, Gene: RBBP7

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Neuroprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Can significantly improve hUC-MSCs proliferation and delay hUC-MSCs aging

23564418

Relation to aging associated genes

No data available

Experimental conditions

29oC

Life Extension

Mean LS (%)
27.3
Median LS (%)
Mortality rate derease (%)
Max LS (%)
37.9
Cell CLS
Cell RLS

Concentration wth maximum effect

10 mkM

More info about experiment

15346199
Opposite effectNo