Trequinsin Hydrochloride
CAS: 78416-81-6
Name:
Trequinsin Hydrochloride
Other names:
Trequinsin hydrochloride; HL 725; Trequinsin, Hydrochloride; TCMDC-125545; NCGC00094424-01; DSSTox_CID_25806; DSSTox_RID_81144
Trequinsin hydrochloride is an ultrapotent (IC50 = 250 pM), highly selective inhibitor of cGMP-inhibited PDE (phosphodiesterase) in vitro. This compound potentiates adenosine-stimulated cAMP accumulation.
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
+
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Agar nematode growth medium + E. coli OP50Life Extension
- Mean LS (%)
- 27.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo