Trehalose

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CAS: 6138-23-4

Name:

Trehalose

Other names:

alpha,alpha-trehalose; Mycose; Ergot sugar; D-Trehalose; alpha-D-Trehalose; D-(+)-Trehalose; alpha-Trehalose; Natural trehalose

Trehalose, is a natural alpha-linked disaccharide formed by an α,α-1,1-glucoside bond between two α-glucose units. It can be synthesised by bacteria, fungi, plants, and invertebrate animals. It is implicated in anhydrobiosis. The sugar is thought to form a gel phase as cells dehydrate, which prevents disruption of internal cell organelles, by effectively splinting them in position. Trehalose has the added advantage of being an antioxidant. Trehalose is currently being used for a broad spectrum of applications [Wiki].

Interactions

Description

UniProt ID

Protein: Taste receptor type 1 member 3, Gene: TAS1R3

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Obesity
Anti Diabetic
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance
+

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Cultured endothelial cells, inhibition of autophagy increased oxidative stress and reduced NO production, whereas trehalose enhanced NO production via an autophagy-dependent mechanism

22570377 20147746

Relation to aging associated genes

No data available

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
32.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

5 mM

More info about experiment

20477758
Opposite effectNo