Trehalose
CAS: 6138-23-4
Name:
Trehalose
Other names:
alpha,alpha-trehalose; Mycose; Ergot sugar; D-Trehalose; alpha-D-Trehalose; D-(+)-Trehalose; alpha-Trehalose; Natural trehalose
Trehalose, is a natural alpha-linked disaccharide formed by an α,α-1,1-glucoside bond between two α-glucose units. It can be synthesised by bacteria, fungi, plants, and invertebrate animals. It is implicated in anhydrobiosis. The sugar is thought to form a gel phase as cells dehydrate, which prevents disruption of internal cell organelles, by effectively splinting them in position. Trehalose has the added advantage of being an antioxidant. Trehalose is currently being used for a broad spectrum of applications [Wiki].
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
No
No
No
Longevity mechanisms activation
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Cultured endothelial cells, inhibition of autophagy increased oxidative stress and reduced NO production, whereas trehalose enhanced NO production via an autophagy-dependent mechanism
Relation to aging associated genes
No data available
Model organism
Experimental conditions
Agar nematode growth medium + E. coli OP50Life Extension
- Mean LS (%)
- 32.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
5 mM