Tannic Acid

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CAS: 1401-55-4

Name:

Tannic Acid

Other names:

Tanninum; DSSTox_CID_6076; 1401-55-4; DSSTox_RID_78006; DSSTox_GSID_26076; Gallotannic acid; Quebracho extract

Gallotannin is an inhibitor of PARG (poly(ADP-ribose) glycohydrolase). Gallotannin is cytoprotective in oxidatively stressed cells. Gallotannin is an inhibitor of NOS3 (eNOS) and a weak inhibitor of NOS2 (iNOS) and NOS1 (nNOS). Gallotannin induces Cox-2 (cyclooxygenase-2) expression and is a free radical scavenger.

Interactions

Description

UniProt ID

Protein: Arginyl-tRNA--protein transferase 1, Gene: ATE1
Protein: Carbonic anhydrase 2, Gene: CA2
Protein: Cytochrome P450, Gene: CYP1A1
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Microtubule-associated protein tau, Gene: MAPT
Protein: Major prion protein, Gene: PRNP

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 2260.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Cancer
Anti Amiloid
Neuroprotective
Antibacterial

19444866.0

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Inhibitory effects of tannic acid on human skin fibroblast elastase activity

[https://www.researchgate.net/publication/264028634_Inhibitory_Effects_of_Tannic_acid_on_Human_Skin_Fibroblast_Elastase_Activity] 16601672

Relation to aging associated genes

TERTMAPT

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
18.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
59.0
Cell CLS
Cell RLS

Concentration wth maximum effect

0,01

More info about experiment

21805983 22114686
Opposite effectNo