Su 4312
CAS: 5812-07-7
Name:
Su 4312
Other names:
SU-4312; SU 4312; NSC86429; 3-(4-Dimethylaminobenzylidenyl)-2-indolinone; 3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one
SU 4312 is a selective and potent vascular endothelial cell growth factor receptor (VEGFR) inhibitor. Inhibition of Flk-1 (VEGFR-2) in neonatal rodent models of stroke, has been shown to limit endothelial cell proliferation and promote cell death. SU 4312 is an inhibitor of Flg, Flt-1 and PDGFR-β.
Interactions
Description
UniProt ID
Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Protein: Receptor tyrosine-protein kinase erbB-2, Gene: ERBB2
Protein: Insulin-like growth factor 1 receptor, Gene: IGF1R
Protein: Platelet-derived growth factor receptor beta, Gene: PDGFRB
Protein: Vascular endothelial growth factor receptor 1, Gene: FLT1
Protein: Vascular endothelial growth factor receptor 2, Gene: KDR
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 5.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo