Su 4312

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CAS: 5812-07-7

Name:

Su 4312

Other names:

SU-4312; SU 4312; NSC86429; 3-(4-Dimethylaminobenzylidenyl)-2-indolinone; 3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one

SU 4312 is a selective and potent vascular endothelial cell growth factor receptor (VEGFR) inhibitor. Inhibition of Flk-1 (VEGFR-2) in neonatal rodent models of stroke, has been shown to limit endothelial cell proliferation and promote cell death. SU 4312 is an inhibitor of Flg, Flt-1 and PDGFR-β.

Interactions

Description

UniProt ID

Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Protein: Receptor tyrosine-protein kinase erbB-2, Gene: ERBB2
Protein: Insulin-like growth factor 1 receptor, Gene: IGF1R
Protein: Platelet-derived growth factor receptor beta, Gene: PDGFRB
Protein: Vascular endothelial growth factor receptor 1, Gene: FLT1
Protein: Vascular endothelial growth factor receptor 2, Gene: KDR

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Cancer
Anti Amiloid
Neuroprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

PDGFRBERBB2IGF1RFLT1

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
5.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo