Staurosporine

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CAS: 62996-74-1

Name:

Staurosporine

Other names:

Staurosporin; Antibiotic 230; (+)-Staurosporine; Antibiotic AM 2282; AM-2282; CCRIS 3272; Alkaloid AM-2282 from Streptomyces

An indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)

Interactions

Description

UniProt ID

Protein: RAC-alpha serine/threonine-protein kinase, Gene: AKT1
Protein: Aurora kinase A-interacting protein, Gene: AURKAIP1
Protein: Tyrosine-protein kinase ABL1, Gene: ABL1
Protein: Proto-oncogene tyrosine-protein kinase Src, Gene: SRC
Gene: CSNK2A1
Protein: Casein kinase II subunit beta, Gene: CSNK2B
Protein: Cyclin-dependent kinase 1, Gene: CDK1
Protein: Cyclin-dependent kinase 2, Gene: CDK2
Gene: CDK4
Protein: Serine/threonine-protein kinase Chk1, Gene: CHEK1
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Elongation factor 1-alpha 1, Gene: EEF1A1
Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Protein: Equilibrative nucleoside transporter 1, Gene: SLC29A1
Protein: Mitogen-activated protein kinase 3, Gene: MAPK3
Protein: Mitogen-activated protein kinase 1, Gene: MAPK1
Protein: Tyrosine-protein kinase Fyn, Gene: FYN
Protein: Glycogen synthase kinase-3 beta, Gene: GSK3B
Protein: Inhibitor of nuclear factor kappa-B kinase subunit beta, Gene: IKBKB
Gene: INSR
Protein: Tyrosine-protein kinase Lck, Gene: LCK
Protein: Macrophage colony-stimulating factor 1 receptor, Gene: CSF1R
Gene: MAP2K1
Protein: 3-phosphoinositide-dependent protein kinase 1, Gene: PDPK1
Protein: Serine/threonine-protein kinase pim-1, Gene: PIM1
Protein: cAMP-dependent protein kinase catalytic subunit alpha, Gene: PRKACA
Gene: PRKACB
Protein: cAMP-dependent protein kinase catalytic subunit gamma, Gene: PRKACG
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Protein kinase C delta type, Gene: PRKCD
Protein: Protein kinase C epsilon type, Gene: PRKCE
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Protein kinase C eta type, Gene: PRKCH
Protein: Protein kinase C iota type, Gene: PRKCI
Protein: Protein kinase C theta type, Gene: PRKCQ
Protein: Protein kinase C zeta type, Gene: PRKCZ
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1
Gene: PRKD2
Protein: Serine/threonine-protein kinase D3, Gene: PRKD3
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1
Protein: Homeobox protein PKNOX1, Gene: PKNOX1
Protein: cGMP-dependent protein kinase 2, Gene: PRKG2
Protein: Tyrosine-protein kinase SYK, Gene: SYK
Protein: Vascular endothelial growth factor receptor 1, Gene: FLT1
Protein: Vascular endothelial growth factor receptor 2, Gene: KDR
Protein: 5-hydroxytryptamine receptor 3A, Gene: HTR3A

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Cancer
Anti Amiloid
Neuroprotective
Antibacterial

No

Antifungal

20435699.0

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Experimental conditions

Not available

Life Extension

Mean LS (%)
34.8
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

30-50 mkM

More info about experiment

22363408
Opposite effectNo