Staurosporine
CAS: 62996-74-1
Name:
Staurosporine
Other names:
Staurosporin; Antibiotic 230; (+)-Staurosporine; Antibiotic AM 2282; AM-2282; CCRIS 3272; Alkaloid AM-2282 from Streptomyces
An indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
Interactions
Description
UniProt ID
Protein: RAC-alpha serine/threonine-protein kinase, Gene: AKT1
Protein: Aurora kinase A-interacting protein, Gene: AURKAIP1
Protein: Tyrosine-protein kinase ABL1, Gene: ABL1
Protein: Proto-oncogene tyrosine-protein kinase Src, Gene: SRC
Gene: CSNK2A1
Protein: Casein kinase II subunit beta, Gene: CSNK2B
Protein: Cyclin-dependent kinase 1, Gene: CDK1
Protein: Cyclin-dependent kinase 2, Gene: CDK2
Gene: CDK4
Protein: Serine/threonine-protein kinase Chk1, Gene: CHEK1
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Elongation factor 1-alpha 1, Gene: EEF1A1
Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Protein: Equilibrative nucleoside transporter 1, Gene: SLC29A1
Protein: Mitogen-activated protein kinase 3, Gene: MAPK3
Protein: Mitogen-activated protein kinase 1, Gene: MAPK1
Protein: Tyrosine-protein kinase Fyn, Gene: FYN
Protein: Glycogen synthase kinase-3 beta, Gene: GSK3B
Protein: Inhibitor of nuclear factor kappa-B kinase subunit beta, Gene: IKBKB
Gene: INSR
Protein: Tyrosine-protein kinase Lck, Gene: LCK
Protein: Macrophage colony-stimulating factor 1 receptor, Gene: CSF1R
Gene: MAP2K1
Protein: 3-phosphoinositide-dependent protein kinase 1, Gene: PDPK1
Protein: Serine/threonine-protein kinase pim-1, Gene: PIM1
Protein: cAMP-dependent protein kinase catalytic subunit alpha, Gene: PRKACA
Gene: PRKACB
Protein: cAMP-dependent protein kinase catalytic subunit gamma, Gene: PRKACG
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Protein kinase C delta type, Gene: PRKCD
Protein: Protein kinase C epsilon type, Gene: PRKCE
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Protein kinase C eta type, Gene: PRKCH
Protein: Protein kinase C iota type, Gene: PRKCI
Protein: Protein kinase C theta type, Gene: PRKCQ
Protein: Protein kinase C zeta type, Gene: PRKCZ
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1
Gene: PRKD2
Protein: Serine/threonine-protein kinase D3, Gene: PRKD3
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1
Protein: Homeobox protein PKNOX1, Gene: PKNOX1
Protein: cGMP-dependent protein kinase 2, Gene: PRKG2
Protein: Tyrosine-protein kinase SYK, Gene: SYK
Protein: Vascular endothelial growth factor receptor 1, Gene: FLT1
Protein: Vascular endothelial growth factor receptor 2, Gene: KDR
Protein: 5-hydroxytryptamine receptor 3A, Gene: HTR3A
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Antibacterial
No
Antifungal
20435699.0
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Model organism
ModelDrosophila melanogaster
SrainOregon-R-C
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 34.8
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
30-50 mkM
More info about experiment
Opposite effectNo