Srt1720
CAS: 1001645-58-4
Name:
Srt1720
Other names:
SRT 1720 Hydrochloride; SRT-1720; SRT 1720; SRT1720; N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide hydrochloride; S1129_Selleck
SRT1720 is an NAD-dependent deacetylase sirtuin-1 (SIRT1) activator (EC50 = 0.16 μM), highly selective for SIRT1 over SIRT2 or SIRT3. Studies in yeast suggest that sirtuins may be involved in epigentic gene silencing and deactylation of proteins that regulate the cell cycle.
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelMice
SrainC57BL/6J
Sex—
Age of treatment28 weeks
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 8.8
- Median LS (%)
- —
- Mortality rate derease (%)
- 27.0
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
100 mg/kg/day
More info about experiment
Opposite effectNo