Spermidine
CAS: 124-20-9
Name:
Spermidine
Other names:
1,5,10-Triazadecane; 4-Azaoctamethylenediamine; Spermidin; N-(3-aminopropyl)butane-1,4-diamine; 4-Azaoctane-1,8-diamine
Spermidine is a polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
Interactions
Description
UniProt ID
Protein: Telomerase Cajal body protein 1, Gene: WRAP53
Protein: Hypoxia-inducible factor 1-alpha, Gene: HIF1A
Protein: Baculoviral IAP repeat-containing protein 7, Gene: BIRC7
Protein: Baculoviral IAP repeat-containing protein 5, Gene: BIRC5
Protein: Sulfate anion transporter 1, Gene: SLC26A1
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
Suppression of aging mechanisms
Induce Autophagy
Relation to biomarkers of Aging
Data not available
Relation to aging associated genes
HIF1AModel organism
ModelSaccharomyces cerevisiae
SrainBY4741
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- 400.0
- Cell RLS
- —
Concentration wth maximum effect
4 mM
More info about experiment
Opposite effectNo
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 15.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0.2 mM
More info about experiment
Opposite effectNo
Model organism
ModelDrosophila melanogaster
Srain—
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 30.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
1 mM
More info about experiment
Opposite effectNo