Warning! Toxic compound!

Sodium Butyrate

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CAS: 156-54-7

Name:

Sodium Butyrate

Other names:

Sodium butanoate; Butyric acid sodium salt; Butanoic acid, sodium salt; Butyrate sodium

Sodium Butyrate has been reported to cause hyperacetylation of histones due to its role as a histone deacetylase (HDAC) inhibitor (IC50 values are 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7 respectively). This compound has been shown to cause induction of differentiation and gene expression and also prevent cell proliferation. Mechanistic studies suggest that the action of Sodium Butyrate is often mediated through Sp1/Sp3-associated HDAC activity which leads to transcriptional activation of the p21 gene. Additionally this agent demonstrates the ability to downregulate numerous genes associated with cytokine signaling, specifically, the IFN-γ (interferon γ) pathway.

Interactions

Description

UniProt ID

Protein: Prostacyclin receptor, Gene: PTGIR

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Obesity
Anti Depressant
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
19.0
Cell CLS
Cell RLS

Concentration wth maximum effect

10 mmol/L

More info about experiment

24003736
Opposite effectNo