Warning! Toxic compound!
Sodium Butyrate
CAS: 156-54-7
Name:
Sodium Butyrate
Other names:
Sodium butanoate; Butyric acid sodium salt; Butanoic acid, sodium salt; Butyrate sodium
Sodium Butyrate has been reported to cause hyperacetylation of histones due to its role as a histone deacetylase (HDAC) inhibitor (IC50 values are 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7 respectively). This compound has been shown to cause induction of differentiation and gene expression and also prevent cell proliferation. Mechanistic studies suggest that the action of Sodium Butyrate is often mediated through Sp1/Sp3-associated HDAC activity which leads to transcriptional activation of the p21 gene. Additionally this agent demonstrates the ability to downregulate numerous genes associated with cytokine signaling, specifically, the IFN-γ (interferon γ) pathway.
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No
No
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- 19.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
10 mmol/L