Simvastatin
CAS: 79902-63-9
Name:
Simvastatin
Other names:
Zocor; Synvinolin; MK-733; Simvastatine; Colemin; Sinvacor; Sivastin; Lipex; Medipo
Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [PubChem]
Interactions
Description
UniProt ID
Gene: NR1I3
Protein: Caspase-3, Gene: CASP3
Protein: Cationic amino acid transporter 2, Gene: SLC7A2
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Cytochrome P450 2B6, Gene: CYP2B6
Protein: Cytochrome P450 2C19, Gene: CYP2C19
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Protein: Cytochrome P450 2D6, Gene: CYP2D6
Protein: Glutathione peroxidase 1, Gene: GPX1
Protein: Superoxide dismutase [Cu-Zn], Gene: SOD1
Protein: Nuclear receptor subfamily 1 group I member 2, Gene: NR1I2
Protein: Superoxide dismutase [Mn], mitochondrial, Gene: SOD2
Protein: Integrin alpha-L, Gene: ITGAL
Protein: Matrix metalloproteinase-9, Gene: MMP9
Protein: Liver carboxylesterase 1, Gene: CES1
Protein: Carboxylic ester hydrolase, Gene: CES2
Protein: Cytochrome P450 2J2, Gene: CYP2J2
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-2, Gene: PRKAA2
Protein: Canalicular multispecific organic anion transporter 1, Gene: ABCC2
Protein: Bile salt export pump, Gene: ABCB11
Gene: SLCO1B1
Protein: Solute carrier family 22 member 5, Gene: SLC22A5
Protein: Ileal sodium/bile acid cotransporter, Gene: SLC10A2
Protein: Solute carrier family 22 member 8, Gene: SLC22A8
Protein: Aldehyde oxidase, Gene: AOX1
Protein: Transforming protein RhoA, Gene: RHOA
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 4438.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Depressant
Neuroprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
Anti Oxidant
Relation to biomarkers of Aging
Antiaging effects of simvastatin on vascular endothelial cells
Model organism
ModelDrosophila melanogaster
SrainOregon-R-C
Sex—
Age of treatment—
Experimental conditions
Standard Cornmeal MediumLife Extension
- Mean LS (%)
- 25.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,24 mM
More info about experiment
Opposite effectNo
Model organism
ModelMice
SrainUM-HET3
Sex—
Age of treatment10 months
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 0.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
12-120 mg/kg food
More info about experiment
Opposite effect20974732