Resveratrol

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CAS: 501-36-0

Name:

Resveratrol

Other names:

3,4',5-Trihydroxystilbene; 3,5,4'-Trihydroxystilbene; Resvida; 3,4',5-Stilbenetriol; (E)-resveratrol

Resveratrol (3,5,4’-trihydroxystilbene) is a polyphenolic phytoalexin. It is a stilbenoid, a derivate of stilbene, and is produced in plants with the help of the enzyme stilbene synthase. It exists as two structural isomers: cis-(Z) and trans-(E), with the trans-isomer shown in the top image. The trans- form can undergo isomerisation to the cis- form when heated or exposed to ultraviolet irradiation. In a 2004 issue of Science, Dr. Sinclair of Harvard University said resveratrol is not an easy molecule to protect from oxidation. It has been claimed that it is readily degraded by exposure to light, heat, and oxygen. However, studies find that Trans-resveratrol undergoes negligible oxidation in normal atmosphere at room temperature. [Wikipedia]

Interactions

Description

UniProt ID

Protein: Aryl hydrocarbon receptor, Gene: AHR
Protein: Cationic amino acid transporter 2, Gene: SLC7A2
Protein: Sperm-specific antigen 2, Gene: SSFA2
Protein: Mitogen-activated protein kinase 1, Gene: MAPK1
Protein: Mitogen-activated protein kinase 3, Gene: MAPK3
Protein: Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, Gene: GPX4
Protein: Mitogen-activated protein kinase 14, Gene: MAPK14
Protein: NAD-dependent protein deacetylase sirtuin-1, Gene: SIRT1
Protein: Superoxide dismutase [Mn], mitochondrial, Gene: SOD2
Gene: Car15
Protein: Carbonic anhydrase 1, Gene: CA1
Protein: Carbonic anhydrase 2, Gene: CA2
Protein: Carbonic anhydrase 3, Gene: CA3
Protein: Carbonic anhydrase 4, Gene: CA4
Protein: Carbonic anhydrase 9, Gene: CA9
Protein: Carbonic anhydrase 5A, mitochondrial, Gene: CA5A
Protein: Carbonic anhydrase 5B, mitochondrial, Gene: CA5B
Protein: Carbonic anhydrase 6, Gene: CA6
Protein: Carbonic anhydrase 7, Gene: CA7
Protein: Carbonic anhydrase 12, Gene: CA12
Protein: Carbonic anhydrase 13, Gene: CA13
Protein: Carbonic anhydrase 14, Gene: CA14
Protein: Prostaglandin G/H synthase 1, Gene: PTGS1
Protein: Cytochrome P450, Gene: CYP1A1
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Gene: CYP1B1
Protein: Cytochrome P450 2A6, Gene: CYP2A6
Protein: Cytochrome P450 2B6, Gene: CYP2B6
Protein: Cytochrome P450 2E1, Gene: CYP2E1
Gene: CYP3A4
Protein: Cytosolic phospholipase A2, Gene: PLA2G4A
Protein: Estrogen sulfotransferase, Gene: SULT1E1
Protein: Tyrosyl-DNA phosphodiesterase 2, Gene: TDP2
Protein: ATP-binding cassette sub-family G member 2, Gene: ABCG2
Protein: Insulin receptor substrate 1, Gene: IRS1
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Obesity
Neuroprotective
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Calorie Restriction Mimetics
Stress Resistance
+

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Data not available

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS
70.0

Concentration wth maximum effect

10 mkM

More info about experiment

12939617
Opposite effectNo

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
Median LS (%)
17.8
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

1 mM

More info about experiment

16256736
Opposite effect17875315

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
Median LS (%)
10.0
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

100 mkM

More info about experiment

15254550
Opposite effect17875315

Experimental conditions

Not available

Life Extension

Mean LS (%)
29.0
Median LS (%)
13.0
Mortality rate derease (%)
Max LS (%)
18.0
Cell CLS
Cell RLS

Concentration wth maximum effect

200 mkM

More info about experiment

15328413
Opposite effect17875315

Experimental conditions

Not available

Life Extension

Mean LS (%)
29.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

10 mkM

More info about experiment

15254550
Opposite effect17875315

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
56.0
Mortality rate derease (%)
Max LS (%)
59.0
Cell CLS
Cell RLS

Concentration wth maximum effect

600 mg/g

More info about experiment

16461283
Opposite effect22451473