Rapamycin

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CAS: 53123-88-9

Name:

Rapamycin

Other names:

Sirolimus; Rapamune; (-)-Rapamycin; AY-22989; WY-090217; NCGC00021305-05; Antibiotic AY 22989

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. [PubChem]

Interactions

Description

UniProt ID

Protein: Equilibrative nucleoside transporter 1, Gene: SLC29A1
Protein: ATP-binding cassette sub-family G member 2, Gene: ABCG2
Protein: Peptidyl-prolyl cis-trans isomerase FKBP10, Gene: FKBP10
Protein: Peptidyl-prolyl cis-trans isomerase FKBP1A, Gene: FKBP1A
Protein: Peptidyl-prolyl cis-trans isomerase FKBP4, Gene: FKBP4
Protein: Peptidyl-prolyl cis-trans isomerase FKBP5, Gene: FKBP5
Protein: Serine/threonine-protein kinase mTOR, Gene: MTOR
Protein: Target of rapamycin complex 2 subunit MAPKAP1, Gene: MAPKAP1
Protein: Target of rapamycin complex subunit LST8, Gene: MLST8
Protein: Serine/threonine-protein kinase mTOR, Gene: MTOR
Protein: Proline-rich protein 5, Gene: PRR5
Protein: Solute carrier organic anion transporter family member 1A2, Gene: SLCO1A2
Gene: SLCO1B1
Protein: Solute carrier organic anion transporter family member 1B3, Gene: SLCO1B3
Protein: Bile salt export pump, Gene: ABCB11

Toxicity

oral LD50 [mouse] mg/kg
> 0.0
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Neuroprotective
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Calorie Restriction Mimetics
Stress Resistance
+

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Currently available evidence seems to best fit a model, wherein rapamycin extends lifespan by suppressing cancers. In addition the drug has symptomatic effects on some aging traits, such as age-related cognitive impairments

25015322 23503511 22170152 22580468 24677687

Relation to aging associated genes

MTORMTOR

Experimental conditions

Not available

Life Extension

Mean LS (%)
7.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
33.0
Cell CLS
Cell RLS

Concentration wth maximum effect

0,5 mkM

More info about experiment

20017609
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
26.0
Mortality rate derease (%)
Max LS (%)
14.0
Cell CLS
Cell RLS

Concentration wth maximum effect

42 ppm

More info about experiment

24341993
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
9.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

More info about experiment

19587680
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
13.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

More info about experiment

19587680
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
7.0
Median LS (%)
11.0
Mortality rate derease (%)
Max LS (%)
8.0
Cell CLS
Cell RLS

Concentration wth maximum effect

14 ppm

More info about experiment

24409289
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
14.0
Median LS (%)
16.0
Mortality rate derease (%)
Max LS (%)
19.0
Cell CLS
Cell RLS

Concentration wth maximum effect

14 ppm

More info about experiment

24409289
Opposite effectNo