Rapamycin
CAS: 53123-88-9
Name:
Rapamycin
Other names:
Sirolimus; Rapamune; (-)-Rapamycin; AY-22989; WY-090217; NCGC00021305-05; Antibiotic AY 22989
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. [PubChem]
Interactions
Description
UniProt ID
Protein: Equilibrative nucleoside transporter 1, Gene: SLC29A1
Protein: ATP-binding cassette sub-family G member 2, Gene: ABCG2
Protein: Peptidyl-prolyl cis-trans isomerase FKBP10, Gene: FKBP10
Protein: Peptidyl-prolyl cis-trans isomerase FKBP1A, Gene: FKBP1A
Protein: Peptidyl-prolyl cis-trans isomerase FKBP4, Gene: FKBP4
Protein: Peptidyl-prolyl cis-trans isomerase FKBP5, Gene: FKBP5
Protein: Serine/threonine-protein kinase mTOR, Gene: MTOR
Protein: Target of rapamycin complex 2 subunit MAPKAP1, Gene: MAPKAP1
Protein: Target of rapamycin complex subunit LST8, Gene: MLST8
Protein: Serine/threonine-protein kinase mTOR, Gene: MTOR
Protein: Proline-rich protein 5, Gene: PRR5
Protein: Solute carrier organic anion transporter family member 1A2, Gene: SLCO1A2
Gene: SLCO1B1
Protein: Solute carrier organic anion transporter family member 1B3, Gene: SLCO1B3
Protein: Bile salt export pump, Gene: ABCB11
Toxicity
- oral LD50 [mouse] mg/kg
- > 0.0
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Neuroprotective
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Calorie Restriction Mimetics
Stress Resistance
+
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Currently available evidence seems to best fit a model, wherein rapamycin extends lifespan by suppressing cancers. In addition the drug has symptomatic effects on some aging traits, such as age-related cognitive impairments
Model organism
ModelDrosophila melanogaster
SrainCanton-S
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 7.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- 33.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,5 mkM
More info about experiment
Opposite effectNo
Model organism
ModelMice
SrainUM-HET3
Sex—
Age of treatment9 months
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- 26.0
- Mortality rate derease (%)
- —
- Max LS (%)
- 14.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
42 ppm
More info about experiment
Opposite effectNo
Model organism
ModelMice
Srainheterogeneous
SexMale
Age of treatment600 days
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 9.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
More info about experiment
Opposite effectNo
Model organism
ModelMice
Srainheterogeneous
SexFemale
Age of treatment600 days
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 13.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
More info about experiment
Opposite effectNo
Model organism
ModelMice
SrainC57BL/6
SexMale
Age of treatment4 months
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 7.0
- Median LS (%)
- 11.0
- Mortality rate derease (%)
- —
- Max LS (%)
- 8.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
14 ppm
More info about experiment
Opposite effectNo
Model organism
ModelMice
SrainC57BL/6
SexFemale
Age of treatment4 months
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 14.0
- Median LS (%)
- 16.0
- Mortality rate derease (%)
- —
- Max LS (%)
- 19.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
14 ppm
More info about experiment
Opposite effectNo