Quinidine Sulfate

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CAS: 50-54-4

Name:

Quinidine Sulfate

Other names:

Kinichron; Quinidate; Quinitex; Systodin; Chinidine sulfate; Quinidine sulphate; Quinidine monosulfate; sk-Quinidine sulfate

An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. [PubChem]

Interactions

No targets available

Toxicity

oral LD50 [mouse] mg/kg
> 505.0
oral LD50 [rat] mg/kg
> 456.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
12.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo