Quinidine Sulfate
CAS: 50-54-4
Name:
Quinidine Sulfate
Other names:
Kinichron; Quinidate; Quinitex; Systodin; Chinidine sulfate; Quinidine sulphate; Quinidine monosulfate; sk-Quinidine sulfate
An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. [PubChem]
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- > 505.0
- oral LD50 [rat] mg/kg
- > 456.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 12.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo