Pyrrolidine Dithiocarbamate

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CAS: 5108-96-3

Name:

Pyrrolidine Dithiocarbamate

Other names:

PDTC; Pyrrolidine dithiocarbamate; Pyrrolidinedithiocarbamate; Pyrrolidine-1-carbodithioic acid; 1-Pyrrolidinecarbodithioic acid; apdc

Pyrrolidine dithiocarbamate and its salts, such as ammonium pyrrolidinecarbodithioate, are used for a variety of biochemical applications including metal chelation, induction of G1 phase cell cycle arrest, and preventing induction of nitric oxide synthase. Compound is inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA [ChEBI].

Interactions

Description

UniProt ID

Protein: Heat shock factor protein 1, Gene: HSF1
Protein: Caspase-3, Gene: CASP3
Protein: Proteasome subunit alpha type-1, Gene: PSMA1
Protein: Proteasome subunit alpha type-2, Gene: PSMA2
Protein: Proteasome subunit alpha type-3, Gene: PSMA3
Protein: Proteasome subunit alpha type-4, Gene: PSMA4
Protein: Proteasome subunit alpha type-5, Gene: PSMA5
Protein: Proteasome subunit alpha type-6, Gene: PSMA6
Protein: Proteasome subunit alpha type-7, Gene: PSMA7
Gene: PSMA8
Protein: Proteasome subunit beta type-1, Gene: PSMB1
Protein: Proteasome subunit beta type-2, Gene: PSMB2
Protein: Proteasome subunit beta type-3, Gene: PSMB3
Protein: Proteasome subunit beta type-4, Gene: PSMB4
Protein: Proteasome subunit beta type-5, Gene: PSMB5
Protein: Proteasome subunit beta type, Gene: PSMB6
Protein: Proteasome subunit beta type, Gene: PSMB7
Protein: Cyclin-dependent kinase 2, Gene: CDK2
Gene: RELA

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Cancer
Anti Amiloid
Neuroprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

LRP2HSF1

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
20.0
Mortality rate derease (%)
Max LS (%)
14.0
Cell CLS
Cell RLS

Concentration wth maximum effect

20 mg/L

More info about experiment

21483034
Opposite effectNo