Warning! Toxic compound!
Pp2
CAS: 172889-27-9
Name:
Pp2
Other names:
InSolution™ PP2; 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; AG 1879
A potent and selective inhibitor of the Src family tyrosine kinases. Inhibits Lck, Fyn, and Hck. It displays weaker inhibition of EGFR and no inhibition of ZAP-70 and JAK2. PP2 is a useful tool for probing the involvement of Src family tyrosine kinases in cellular signaling [Enzo Life Sciences].
Interactions
Description
UniProt ID
Protein: Tyrosine-protein kinase ABL1, Gene: ABL1
Protein: Proto-oncogene tyrosine-protein kinase Src, Gene: SRC
Protein: Equilibrative nucleoside transporter 1, Gene: SLC29A1
Protein: Tyrosine-protein kinase Lck, Gene: LCK
Protein: Mitogen-activated protein kinase 14, Gene: MAPK14
Protein: Serine/threonine-protein kinase WNK1, Gene: WNK1
Protein: Casein kinase I isoform delta, Gene: CSNK1D
Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
"Selective" inhibitor for Src-family kinases. Treat senescence-associated apoptosis resistance
Model organism
ModelDrosophila melanogaster
SrainOregon-R-C
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 22.8
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
300 mkM
More info about experiment
Opposite effectNo