Pioglitazone

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CAS: 111025-46-8

Name:

Pioglitazone

Other names:

Actos; Pioglitazona; Pioglitazonum; Glustin; Actost; Zactos; Pioglitazonum [INN-Latin]

Pioglitazone is used for the treatment of diabetes mellitus type 2. Pioglitazone selectively stimulates nuclear receptor peroxisone proliferator-activated receptor gamma (PPAR-gamma). It modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the lipidic, muscular tissues and in the liver.

Interactions

Description

UniProt ID

Protein: Peroxisome proliferator-activated receptor alpha, Gene: PPARA
Protein: Constitutive coactivator of peroxisome proliferator-activated receptor gamma, Gene: FAM120B
Protein: cAMP-dependent protein kinase catalytic subunit alpha, Gene: PRKACA
Gene: PRKACB
Protein: cAMP-dependent protein kinase catalytic subunit gamma, Gene: PRKACG
Protein: Liver carboxylesterase 1, Gene: CES1
Protein: Carboxylic ester hydrolase, Gene: CES2
Protein: Cytochrome P450 2C8, Gene: CYP2C8
Gene: CYP3A4
Protein: Amine oxidase [flavin-containing] B, Gene: MAOB
Protein: Serine/threonine-protein kinase mTOR, Gene: MTOR
Gene: SLCO1B1
Protein: Ileal sodium/bile acid cotransporter, Gene: SLC10A2
Protein: Bile salt export pump, Gene: ABCB11
Protein: Solute carrier organic anion transporter family member 1B3, Gene: SLCO1B3

Toxicity

oral LD50 [mouse] mg/kg
> 181.0
oral LD50 [rat] mg/kg
> 558.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Anti Diabetic
Anti Depressant
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

Anti Age

Relation to biomarkers of Aging

PPAR-γ activator, leads to improvements in muscle power during voluntary weight loss in older adults; Up-regulates telomerase activity

23292287 21396644

Relation to aging associated genes

PRKCAPPARAMTOR

Experimental conditions

Not available

Life Extension

Mean LS (%)
3.7
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,02 mg/ml

More info about experiment

17628757
Opposite effectNo