Pioglitazone
CAS: 111025-46-8
Name:
Pioglitazone
Other names:
Actos; Pioglitazona; Pioglitazonum; Glustin; Actost; Zactos; Pioglitazonum [INN-Latin]
Pioglitazone is used for the treatment of diabetes mellitus type 2. Pioglitazone selectively stimulates nuclear receptor peroxisone proliferator-activated receptor gamma (PPAR-gamma). It modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the lipidic, muscular tissues and in the liver.
Interactions
Description
UniProt ID
Protein: Peroxisome proliferator-activated receptor alpha, Gene: PPARA
Protein: Constitutive coactivator of peroxisome proliferator-activated receptor gamma, Gene: FAM120B
Protein: cAMP-dependent protein kinase catalytic subunit alpha, Gene: PRKACA
Gene: PRKACB
Protein: cAMP-dependent protein kinase catalytic subunit gamma, Gene: PRKACG
Protein: Liver carboxylesterase 1, Gene: CES1
Protein: Carboxylic ester hydrolase, Gene: CES2
Protein: Cytochrome P450 2C8, Gene: CYP2C8
Gene: CYP3A4
Protein: Amine oxidase [flavin-containing] B, Gene: MAOB
Protein: Serine/threonine-protein kinase mTOR, Gene: MTOR
Gene: SLCO1B1
Protein: Ileal sodium/bile acid cotransporter, Gene: SLC10A2
Protein: Bile salt export pump, Gene: ABCB11
Protein: Solute carrier organic anion transporter family member 1B3, Gene: SLCO1B3
Toxicity
- oral LD50 [mouse] mg/kg
- > 181.0
- oral LD50 [rat] mg/kg
- > 558.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Anti Diabetic
Anti Depressant
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
Anti Age
Relation to biomarkers of Aging
PPAR-γ activator, leads to improvements in muscle power during voluntary weight loss in older adults; Up-regulates telomerase activity
Model organism
ModelDrosophila melanogaster
SrainIves (IV) population
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 3.7
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,02 mg/ml
More info about experiment
Opposite effectNo