Phosphonoformic Acid
CAS: 4428-95-9
Name:
Phosphonoformic Acid
Other names:
Foscarnet; Phosphonoformate; Carboxyphosphonic acid; Foscarmet; Foscavir; Triapten; Phgosphonocarboxylic acid
An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV. [PubChem]
Interactions
Description
UniProt ID
Protein: Carbonic anhydrase 1, Gene: CA1
Protein: Carbonic anhydrase 2, Gene: CA2
Protein: Carbonic anhydrase 4, Gene: CA4
Protein: Carbonic anhydrase 9, Gene: CA9
Protein: Carbonic anhydrase 5A, mitochondrial, Gene: CA5A
Protein: Carbonic anhydrase 5B, mitochondrial, Gene: CA5B
Protein: Carbonic anhydrase 6, Gene: CA6
Protein: Carbonic anhydrase 7, Gene: CA7
Protein: Carbonic anhydrase-related protein, Gene: CA8
Protein: Carbonic anhydrase 12, Gene: CA12
Protein: Carbonic anhydrase 14, Gene: CA14
Protein: DNA polymerase alpha catalytic subunit, Gene: POLA1
Protein: DNA polymerase alpha subunit B, Gene: POLA2
Protein: DNA polymerase delta catalytic subunit, Gene: POLD1
Protein: DNA polymerase delta subunit 4, Gene: POLD4
Protein: DNA polymerase delta subunit 2, Gene: POLD2
Protein: DNA polymerase delta subunit 3, Gene: POLD3
Protein: DNA polymerase subunit gamma-1, Gene: POLG
Protein: DNA polymerase subunit gamma-2, mitochondrial, Gene: POLG2
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataModel organism
ModelDrosophila melanogaster
SrainCanton-S
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 5.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
6 mkM
More info about experiment
Opposite effectNo