Phenformin
CAS: 114-86-3
Name:
Phenformin
Other names:
Phenformine; Fenformin; Fenformina; Phenylethylbiguanide; Normoglucina; Phenforminum; Cronoformin; Feguanide; Fenfoduron
A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Interactions
Description
UniProt ID
Protein: Glutathione-specific gamma-glutamylcyclotransferase 1, Gene: CHAC1
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-2, Gene: PRKAA2
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-1, Gene: PRKAA1
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-2, Gene: PRKAA2
Protein: Multidrug and toxin extrusion protein 1, Gene: SLC47A1
Protein: Multidrug and toxin extrusion protein 2, Gene: SLC47A2
Protein: Solute carrier family 22 member 2, Gene: SLC22A2
Protein: Cathepsin B, Gene: CTSB
Protein: Cytochrome P450 2D26, Gene: Cyp2d26
Protein: Cytochrome P450 2D6, Gene: CYP2D6
Protein: Amiloride-sensitive sodium channel subunit alpha, Gene: SCNN1A
Gene: SCNN1B
Protein: Amiloride-sensitive sodium channel subunit delta, Gene: SCNN1D
Protein: Amiloride-sensitive sodium channel subunit gamma, Gene: SCNN1G
Protein: RAC-alpha serine/threonine-protein kinase, Gene: AKT1
Protein: RAC-beta serine/threonine-protein kinase, Gene: AKT2
Protein: RAC-gamma serine/threonine-protein kinase, Gene: AKT3
Protein: Glycogen synthase kinase-3 alpha, Gene: GSK3A
Protein: Glycogen synthase kinase-3 beta, Gene: GSK3B
Toxicity
- oral LD50 [mouse] mg/kg
- > 407.0
- oral LD50 [rat] mg/kg
- > 938.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Cancer
Anti Obesity
Anti Diabetic
Neuroprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Calorie Restriction Mimetics
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Model organism
ModelMice
SrainC3H/Sn
SexFemale
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 23.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- 26.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
2 mg/day
More info about experiment
Opposite effectNo
Model organism
ModelRat
SrainLIO
SexFemale
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- 10.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
5 mg/day
More info about experiment
Opposite effectNo