Oxatomide

Imageshandler

CAS: 60607-34-3

Name:

Oxatomide

Other names:

Tinset; Oxatimide; Celtect; Oxatomida; Oxetal; Oxatomidum; KW-4354; Oxatomidum [INN-Latin]

Oxatomide is a phenylpiperazine which acts as an H1 receptor antagonist. An interesting characteristic of Oxatomide is that it does not block acetylcholine in the central and peripheral nervous system. Studies conducted on guinea pigs show that Oxatomide suppresses PAF-induced bronchoconstriction and inhibits the release of leukotrienes and other mediators. Alternate studies show that the effectiveness of Oxatomide is not altered as a result of pretreating the cells with histamine, which is observed in other H1 receptor antagonists such as Fexofenadine (sc-218475). It is believed that Oxatomide's lipophilic properties allow it to cross the plasma membrane of cells.

Interactions

Description

UniProt ID

Gene: DRD3
Protein: Nuclear receptor subfamily 1 group I member 2, Gene: NR1I2
Protein: Voltage-dependent L-type calcium channel subunit alpha-1D, Gene: CACNA1D
Protein: D(1A) dopamine receptor, Gene: DRD1
Protein: D(2) dopamine receptor, Gene: DRD2
Protein: ATP-dependent RNA helicase DHX8, Gene: DHX8
Protein: Cytosolic phospholipase A2, Gene: PLA2G4A
Protein: Cytosolic phospholipase A2 gamma, Gene: PLA2G4C
Protein: Cytochrome P450 2D6, Gene: CYP2D6
Gene: CYP3A4

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 1410.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
25.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo