Oleoylethanolamide
CAS: 111-58-0
Name:
Oleoylethanolamide
Other names:
oleoylethanolamide; N-(2-Hydroxyethyl)oleamide; Oleylethanolamide; Oleamide MEA; N-oleoyl ethanolamine; Oleoyl monoethanolamide
Oleylethanolamide is a naturally occurring lipid analogue of the endogenous cannabinoid anandamide (sc-200790). This compound has been noted to be produced in cells and is quickly eliminated by enzymatic hydrolysis. Experiments suggest that Oleylethanolamide causes activation of Neu/ErbB2 receptors and is a selective agonist of GPR55. It is also an endogenous agonist at the GPR119 receptor. Additional studies suggest that this agent can cause Sr/Thr phosphorylation of Glut4 via partial mediation of p38 and JNK kinases. Oleylethanolime has been noted to also regulate the expression of various PPAR-α target genes. Oleylethanolamide is an inhibitor of Acid Ceramidase and an activator of PPARα and VR1.
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataNo
No
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 15.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
100 mkM