Nordihydroguaiaretic Acid

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CAS: 500-38-9

Name:

Nordihydroguaiaretic Acid

Other names:

NDGA, masoprocol; Dihydronorguaiaretic acid; Norhydroguaiaretic acid; Nordihydroguairaretic acid

A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. [PubChem]

Interactions

Description

UniProt ID

Protein: Arachidonate 12-lipoxygenase, 12S-type, Gene: ALOX12
Protein: Arachidonate 15-lipoxygenase, Gene: ALOX15
Protein: Arachidonate 5-lipoxygenase, Gene: ALOX5
Protein: Cyclic AMP-dependent transcription factor ATF-2, Gene: ATF2
Protein: Proto-oncogene c-Fos, Gene: FOS
Protein: Protein fosB, Gene: FOSB
Protein: Fos-related antigen 1, Gene: FOSL1
Protein: Fos-related antigen 2, Gene: FOSL2
Protein: Transcription factor AP-1, Gene: JUN
Protein: Transcription factor jun-B, Gene: JUNB
Protein: Transcription factor jun-D, Gene: JUND
Protein: Liver carboxylesterase 1, Gene: CES1
Protein: Receptor tyrosine-protein kinase erbB-2, Gene: ERBB2
Protein: Carboxylesterase 1E, Gene: Ces1e
Gene: FASN
Protein: Insulin-like growth factor 1 receptor, Gene: IGF1R
Protein: TGF-beta receptor type-1, Gene: TGFBR1
Protein: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, Gene: SAMHD1
Protein: Mothers against decapentaplegic homolog 2, Gene: SMAD2

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Obesity
Anti Diabetic
Neuroprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

ATF2FOSJUNDJUNDERBB2IGF1R

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
23.0
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

3mg/ml

More info about experiment

25380600
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
12.0
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

More info about experiment

18631321
Opposite effectNo