Nordihydroguaiaretic Acid
CAS: 500-38-9
Name:
Nordihydroguaiaretic Acid
Other names:
NDGA, masoprocol; Dihydronorguaiaretic acid; Norhydroguaiaretic acid; Nordihydroguairaretic acid
A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. [PubChem]
Interactions
Description
UniProt ID
Protein: Arachidonate 12-lipoxygenase, 12S-type, Gene: ALOX12
Protein: Arachidonate 15-lipoxygenase, Gene: ALOX15
Protein: Arachidonate 5-lipoxygenase, Gene: ALOX5
Protein: Cyclic AMP-dependent transcription factor ATF-2, Gene: ATF2
Protein: Proto-oncogene c-Fos, Gene: FOS
Protein: Protein fosB, Gene: FOSB
Protein: Fos-related antigen 1, Gene: FOSL1
Protein: Fos-related antigen 2, Gene: FOSL2
Protein: Transcription factor AP-1, Gene: JUN
Protein: Transcription factor jun-B, Gene: JUNB
Protein: Transcription factor jun-D, Gene: JUND
Protein: Liver carboxylesterase 1, Gene: CES1
Protein: Receptor tyrosine-protein kinase erbB-2, Gene: ERBB2
Protein: Carboxylesterase 1E, Gene: Ces1e
Gene: FASN
Protein: Insulin-like growth factor 1 receptor, Gene: IGF1R
Protein: TGF-beta receptor type-1, Gene: TGFBR1
Protein: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, Gene: SAMHD1
Protein: Mothers against decapentaplegic homolog 2, Gene: SMAD2
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Obesity
Anti Diabetic
Neuroprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Model organism
ModelDrosophila melanogaster
SrainOregon-R-C
SexMale
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- 23.0
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
3mg/ml
More info about experiment
Opposite effectNo
Model organism
ModelMice
SrainUM-HET3
SexMale
Age of treatment6 months
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- 12.0
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
More info about experiment
Opposite effectNo