Nitroflurbiprofen
CAS: 158836-71-6
Name:
Nitroflurbiprofen
Other names:
Flurbinitroxybutylester; Nitroxybutyl flurbiprofen; 4-(Nitrooxy)butyl 2-fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetate
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins [ChEBI].
Interactions
Description
UniProt ID
Protein: Constitutive coactivator of peroxisome proliferator-activated receptor gamma, Gene: FAM120B
Protein: Prostaglandin G/H synthase 2, Gene: PTGS2
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
ModelMice
SrainUM-HET3
Sex—
Age of treatment4 months
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- 12.0
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
200 mg/kg of food
More info about experiment
Opposite effectNo