Nitrendipine
CAS: 39562-70-4
Name:
Nitrendipine
Other names:
Bayotensin; Baypress; Nidrel; Nitrendipino; Nitrendipinum; Deiten; Bylotensin; Nitrepin
A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. [PubChem]
Interactions
Description
UniProt ID
Protein: Adenosine receptor A1, Gene: ADORA1
Protein: Putative uncharacterized protein ADORA2A-AS1, Gene: ADORA2A-AS1
Gene: ADORA3
Protein: Voltage-dependent T-type calcium channel subunit alpha-1G, Gene: CACNA1G
Protein: Voltage-dependent T-type calcium channel subunit alpha-1I, Gene: CACNA1I
Gene: CACNA2D1
Protein: Voltage-dependent L-type calcium channel subunit beta-1, Gene: CACNB1
Protein: Voltage-dependent L-type calcium channel subunit beta-2, Gene: CACNB2
Protein: Voltage-dependent L-type calcium channel subunit beta-3, Gene: CACNB3
Protein: Voltage-dependent L-type calcium channel subunit beta-4, Gene: CACNB4
Protein: Voltage-dependent calcium channel gamma-1 subunit, Gene: CACNG1
Protein: Gonadotropin-releasing hormone receptor, Gene: GNRHR
Protein: Potassium voltage-gated channel subfamily H member 2, Gene: KCNH2
Gene: KCNH5
Protein: Potassium voltage-gated channel subfamily H member 1, Gene: KCNH1
Protein: Voltage-dependent L-type calcium channel subunit alpha-1C, Gene: CACNA1C
Protein: Intermediate conductance calcium-activated potassium channel protein 4, Gene: KCNN4
Protein: Ileal sodium/bile acid cotransporter, Gene: SLC10A2
Protein: Transthyretin, Gene: TTR
Gene: CYP3A4
Protein: Voltage-dependent T-type calcium channel subunit alpha-1H, Gene: CACNA1H
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 15370.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
+
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 25.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo