Nicotinamide Adenine Dinucleotide

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CAS: 53-84-9

Name:

Nicotinamide Adenine Dinucleotide

Other names:

nadide; Codehydrase I; NAD+; Cozymase I; Codehydrogenase I; diphosphopyridine nucleotide; beta-NAD

Is a coenzyme found in all living cells. The compound is a dinucleotide, because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base and the other nicotinamid. Nicotinamide adenine dinucleotide exists in two forms, an oxidized and reduced form abbreviated as NAD+ and NADH respectively. NAD participates in many redox reactions in cells, including glycolysis and most of those, the citric acid cycle of cellular respiration [Wiki]

Interactions

Description

UniProt ID

Protein: Dihydropteridine reductase, Gene: QDPR
Protein: Circadian locomoter output cycles protein kaput, Gene: CLOCK
Gene: NPAS2

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Amiloid
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance
+

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Improve cognitive functioning in patients with Parkinson's disease, depression and AD

15134388

Relation to aging associated genes

CLOCK

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
15.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

100 mkM

More info about experiment

19370397
Opposite effectNo