Nicardipine Hydrochloride
CAS: 54527-84-3
Name:
Nicardipine Hydrochloride
Other names:
Cardene; Nicardipine HCl; Nicodel; Perdipine; Loxen; YC-93; Angioglebil
Nicardipine hydrochloride is the hydrochloride salt preparation of Nicardipine and a potent L-type calcium channel protein inhibitor. Nicardipine is described to alter cytochrome P-450 3A expression through induction of CYP3A. Nicardipine blockade of Ca2+ channels has been correlated to antihypertensive effects.
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 184.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Atherogenic
Neuroprotective
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
Anti Oxidant
Relation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 23.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo