N-(2-[4-(4-Chlorophenyl)Piperazin-1-Yl]Ethyl)-3-Methoxybenzamide
CAS: 219125-63-0
Name:
N-(2-[4-(4-Chlorophenyl)Piperazin-1-Yl]Ethyl)-3-Methoxybenzamide
Other names:
N-[2-(4-(4-Chlorophenyl)piperazin-1-yl)ethyl]-3-methoxybenzamide; N-(2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl)-3-methoxybenzamide
A selective and potent ligand for the D4 dopamine receptor.
Interactions
Description
UniProt ID
Gene: DRD3
Protein: Alpha-1A adrenergic receptor, Gene: ADRA1A
Protein: Alpha-1B adrenergic receptor, Gene: ADRA1B
Protein: Alpha-1D adrenergic receptor, Gene: ADRA1D
Protein: D(2) dopamine receptor, Gene: DRD2
Protein: D(4) dopamine receptor, Gene: DRD4
Protein: 5-hydroxytryptamine receptor 1A, Gene: HTR1A
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataAntibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
+
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 35.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo