N-(2-[4-(4-Chlorophenyl)Piperazin-1-Yl]Ethyl)-3-Methoxybenzamide

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CAS: 219125-63-0

Name:

N-(2-[4-(4-Chlorophenyl)Piperazin-1-Yl]Ethyl)-3-Methoxybenzamide

Other names:

N-[2-(4-(4-Chlorophenyl)piperazin-1-yl)ethyl]-3-methoxybenzamide; N-(2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl)-3-methoxybenzamide

A selective and potent ligand for the D4 dopamine receptor.

Interactions

Description

UniProt ID

Gene: DRD3
Protein: Alpha-1A adrenergic receptor, Gene: ADRA1A
Protein: Alpha-1B adrenergic receptor, Gene: ADRA1B
Protein: Alpha-1D adrenergic receptor, Gene: ADRA1D
Protein: D(2) dopamine receptor, Gene: DRD2
Protein: D(4) dopamine receptor, Gene: DRD4
Protein: 5-hydroxytryptamine receptor 1A, Gene: HTR1A

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

No data
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance
+

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
35.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo