Morphine
CAS: 57-27-2
Name:
Morphine
Other names:
morphine
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. [PubChem]
Interactions
Description
UniProt ID
Protein: Delta-type opioid receptor, Gene: OPRD1
Protein: Kappa-type opioid receptor, Gene: OPRK1
Protein: Mu-type opioid receptor, Gene: OPRM1
Protein: Sigma non-opioid intracellular receptor 1, Gene: SIGMAR1
Protein: Potassium voltage-gated channel subfamily H member 2, Gene: KCNH2
Gene: KCNH5
Protein: Prostaglandin G/H synthase 2, Gene: PTGS2
Protein: G protein-regulated inducer of neurite outgrowth 1, Gene: GPRIN1
Protein: Glutamate receptor ionotropic, NMDA 2A, Gene: GRIN2A
Protein: Glutamate receptor ionotropic, NMDA 2B, Gene: GRIN2B
Protein: Glutamate receptor ionotropic, NMDA 2C, Gene: GRIN2C
Protein: Glutamate receptor ionotropic, NMDA 2D, Gene: GRIN2D
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 973.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
ModelDrosophila melanogaster
SrainOregon-R-C
Sex—
Age of treatment5 day
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 15.5
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,05 mg/ml
More info about experiment
Opposite effectNo