Methiothepin

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CAS: 20229-30-5

Name:

Methiothepin

Other names:

Metitepine; Methiothepine; Metitepinum; Metitepina; Metitepine [INN]; Metitepinum [INN-Latin]; Metitepina [INN-Spanish]

Metitepine (INN), also commonly known as methiothepin, is a drug that acts as an antagonist at various serotonin and dopamine receptors. It is used as an antipsychotic. [Wikipedia]

Interactions

Description

UniProt ID

Protein: 5-hydroxytryptamine receptor 1B, Gene: HTR1B
Protein: D(1A) dopamine receptor, Gene: DRD1
Protein: D(2) dopamine receptor, Gene: DRD2
Protein: ATP-dependent RNA helicase DHX8, Gene: DHX8
Protein: 5-hydroxytryptamine receptor 1A, Gene: HTR1A
Protein: 5-hydroxytryptamine receptor 1D, Gene: HTR1D
Protein: 5-hydroxytryptamine receptor 1E, Gene: HTR1E
Protein: 5-hydroxytryptamine receptor 1F, Gene: HTR1F
Protein: 5-hydroxytryptamine receptor 2A, Gene: HTR2A
Protein: 5-hydroxytryptamine receptor 2B, Gene: HTR2B
Protein: 5-hydroxytryptamine receptor 2C, Gene: HTR2C
Protein: 5-hydroxytryptamine receptor 6, Gene: HTR6
Protein: 5-hydroxytryptamine receptor 7, Gene: HTR7
Protein: 5-hydroxytryptamine receptor 1A, Gene: HTR1A
Protein: 5-hydroxytryptamine receptor 1B, Gene: HTR1B
Protein: 5-hydroxytryptamine receptor 3A, Gene: HTR3A
Protein: 5-hydroxytryptamine receptor 3B, Gene: HTR3B
Protein: 5-hydroxytryptamine receptor 3C, Gene: HTR3C
Protein: 5-hydroxytryptamine receptor 4, Gene: HTR4
Protein: 5-hydroxytryptamine receptor 5A, Gene: HTR5A
Gene: HTR5BP

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Depressant
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Calorie Restriction Mimetics

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

liquid medium + E. coli OP50

Life Extension

Mean LS (%)
25.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

10 mkM

More info about experiment

18033297
Opposite effect19112515