Methionine Sulfoximine
CAS: 15985-39-4
Name:
Methionine Sulfoximine
Other names:
2-Amino-4-(S-methylsulfonimidoyl)butanoic acid; DL-Methionine DL-sulfoximine; Methionine-rs-sulfoximine, L-; CCRIS 5096
Methionine Sulfoximine (MSO): MSO is an inhibitor that binds to the glutamate site. Bound to glutamine synthase (GS), MSO is phosphorylated by ATP that results in an irreversible, non-covalent inhibition of GS [Wikipedia]
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataAntibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelSaccharomyces cerevisiae
SrainBY4743
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- 100.0
- Cell RLS
- —
Concentration wth maximum effect
400 mkM
More info about experiment
Opposite effectNo