Metergoline
CAS: 17692-51-2
Name:
Metergoline
Other names:
Liserdol; Metergolina; Methergoline; Metergolin; Metergolinum; Metergolina [DCIT]; Metergolinum [Latin]; Metergolina [Spanish]
Metergoline is an antagonist at 5-HT1, 5-HT2, and SR-7 (5-HT7) serotonin receptors; also SR-1D (5-HT1D) ligand. Metergoline shows moderate affinity for 5-HT6 and high affinity for 5-HT7.
Interactions
Description
UniProt ID
Protein: ATP-dependent RNA helicase DHX8, Gene: DHX8
Protein: 5-hydroxytryptamine receptor 1B, Gene: HTR1B
Protein: 5-hydroxytryptamine receptor 1D, Gene: HTR1D
Protein: Acetylcholinesterase, Gene: ACHE
Protein: 5-hydroxytryptamine receptor 1A, Gene: HTR1A
Protein: 5-hydroxytryptamine receptor 1E, Gene: HTR1E
Protein: 5-hydroxytryptamine receptor 2A, Gene: HTR2A
Protein: 5-hydroxytryptamine receptor 2C, Gene: HTR2C
Protein: 5-hydroxytryptamine receptor 5A, Gene: HTR5A
Protein: 5-hydroxytryptamine receptor 6, Gene: HTR6
Protein: 5-hydroxytryptamine receptor 7, Gene: HTR7
Protein: 5-hydroxytryptamine receptor 1A, Gene: HTR1A
Protein: 5-hydroxytryptamine receptor 1B, Gene: HTR1B
Protein: 5-hydroxytryptamine receptor 1D, Gene: HTR1D
Protein: 5-hydroxytryptamine receptor 1E, Gene: HTR1E
Protein: 5-hydroxytryptamine receptor 1F, Gene: HTR1F
Protein: 5-hydroxytryptamine receptor 2A, Gene: HTR2A
Protein: 5-hydroxytryptamine receptor 2B, Gene: HTR2B
Protein: 5-hydroxytryptamine receptor 2C, Gene: HTR2C
Protein: 5-hydroxytryptamine receptor 3A, Gene: HTR3A
Protein: 5-hydroxytryptamine receptor 3B, Gene: HTR3B
Protein: 5-hydroxytryptamine receptor 3C, Gene: HTR3C
Protein: 5-hydroxytryptamine receptor 4, Gene: HTR4
Protein: 5-hydroxytryptamine receptor 5A, Gene: HTR5A
Gene: HTR5BP
Protein: 5-hydroxytryptamine receptor 6, Gene: HTR6
Protein: 5-hydroxytryptamine receptor 7, Gene: HTR7
Protein: Bile salt export pump, Gene: ABCB11
Protein: Multidrug resistance protein 1, Gene: ABCB1
Toxicity
- oral LD50 [mouse] mg/kg
- > 430.0
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataAntibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
+
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 23.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo