Loratadine
CAS: 79794-75-5
Name:
Loratadine
Other names:
Claritin; Loratidine; Alavert; Clarityn; Clarityne; Fristamin; Histaloran; Loracert
Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. [PubChem]
Interactions
Description
UniProt ID
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Protein: Nuclear receptor subfamily 1 group I member 2, Gene: NR1I2
Protein: ATP-dependent RNA helicase DHX8, Gene: DHX8
Protein: Potassium voltage-gated channel subfamily H member 2, Gene: KCNH2
Gene: KCNH5
Protein: Potassium voltage-gated channel subfamily A member 5, Gene: KCNA5
Protein: Potassium voltage-gated channel subfamily H member 1, Gene: KCNH1
Protein: Cytochrome P450 2C19, Gene: CYP2C19
Protein: Cytochrome P450 2C8, Gene: CYP2C8
Protein: Cytochrome P450 2D6, Gene: CYP2D6
Protein: Cytochrome P450 2J2, Gene: CYP2J2
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 0.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 18.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo