Loratadine

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CAS: 79794-75-5

Name:

Loratadine

Other names:

Claritin; Loratidine; Alavert; Clarityn; Clarityne; Fristamin; Histaloran; Loracert

Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. [PubChem]

Interactions

Description

UniProt ID

Protein: Cytochrome P450 2C9, Gene: CYP2C9
Protein: Nuclear receptor subfamily 1 group I member 2, Gene: NR1I2
Protein: ATP-dependent RNA helicase DHX8, Gene: DHX8
Protein: Potassium voltage-gated channel subfamily H member 2, Gene: KCNH2
Gene: KCNH5
Protein: Potassium voltage-gated channel subfamily A member 5, Gene: KCNA5
Protein: Potassium voltage-gated channel subfamily H member 1, Gene: KCNH1
Protein: Cytochrome P450 2C19, Gene: CYP2C19
Protein: Cytochrome P450 2C8, Gene: CYP2C8
Protein: Cytochrome P450 2D6, Gene: CYP2D6
Protein: Cytochrome P450 2J2, Gene: CYP2J2

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 0.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance
+

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
18.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo