Lithocholic Acid
CAS: 434-13-9
Name:
Lithocholic Acid
Other names:
Lithocholate; 3alpha-Hydroxy-5beta-cholanic acid; Lithocolic acid; 3-Hydroxycholan-24-oic acid
Lithocholic acid is a bile acid used to assess cholestasis and it acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
Interactions
Description
UniProt ID
Protein: G-protein coupled bile acid receptor 1, Gene: GPBAR1
Protein: Nuclear receptor subfamily 1 group I member 2, Gene: NR1I2
Protein: Vitamin D3 receptor, Gene: VDR
Protein: Alpha-1-antitrypsin, Gene: SERPINA1
Protein: Solute carrier family 10 member 6, Gene: SLC10A6
Protein: Glutathione S-transferase A1, Gene: GSTA1
Protein: Corticosteroid 11-beta-dehydrogenase isozyme 2, Gene: HSD11B2
Protein: Corticosteroid 11-beta-dehydrogenase isozyme 1, Gene: HSD11B1
Toxicity
- oral LD50 [mouse] mg/kg
- > 3900.0
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
ModelSaccharomyces cerevisiae
SrainBY4742
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- 200.0
- Cell RLS
- —
Concentration wth maximum effect
50 mkM
More info about experiment
Opposite effectNo