Lithium Chloride
CAS: 7447-41-8
Name:
Lithium Chloride
Other names:
Lithium chloride (LiCl); chlorure de lithium; Lithiumchlorid; Chlorku litu; chlorolithium; Luthium chloride; LiCl
Lithium Chloride is an antiviral metal halide utilized in a variety of assays to study cell-fate and neurobiology. In developingXenopus embryos, lithium chloride is observed to exert inhibition of GSK-3β (glycogen synthase kinase-3β), yet not reported to be a general inhibitor of other protein kinases. These observations may have implications for lithium chloride on cell-fate determination in several organisms including Xenopus and Dictyostelium. Additionally, in transfected Chinese Hamster Ovary cells (CHO) stimulated with angiotension II (Ang II), it was noted that lithium chloride enhanced the production of inositol triphosphate. The antiviral properties of lithium chloride were noted in a study which showed that the compound inhibited pseudorabis virus infection in vitro. In Drosophila, it was observed that in the nervous system, lithium chloride may have an effect on amino acid metabolism. Futhermore, in glial primary cell cultures, lithium chloride has been noted to provide protection against glutamate excitotoxicity by potentially reducing NR1 mRNA, the major N-methyl-D-aspartate receptor (NMDAR) subunit in the cells.
Interactions
Description
UniProt ID
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 526.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No
No
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
GSK3BModel organism
Experimental conditions
Agar nematode growth medium + streptomycin-resistant E. coli OP50-1 25,5oCLife Extension
- Mean LS (%)
- 10.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
10 mM
More info about experiment
Model organism
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- 0.0
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —