Lithium Chloride

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CAS: 7447-41-8

Name:

Lithium Chloride

Other names:

Lithium chloride (LiCl); chlorure de lithium; Lithiumchlorid; Chlorku litu; chlorolithium; Luthium chloride; LiCl

Lithium Chloride is an antiviral metal halide utilized in a variety of assays to study cell-fate and neurobiology. In developingXenopus embryos, lithium chloride is observed to exert inhibition of GSK-3β (glycogen synthase kinase-3β), yet not reported to be a general inhibitor of other protein kinases. These observations may have implications for lithium chloride on cell-fate determination in several organisms including Xenopus and Dictyostelium. Additionally, in transfected Chinese Hamster Ovary cells (CHO) stimulated with angiotension II (Ang II), it was noted that lithium chloride enhanced the production of inositol triphosphate. The antiviral properties of lithium chloride were noted in a study which showed that the compound inhibited pseudorabis virus infection in vitro. In Drosophila, it was observed that in the nervous system, lithium chloride may have an effect on amino acid metabolism. Futhermore, in glial primary cell cultures, lithium chloride has been noted to provide protection against glutamate excitotoxicity by potentially reducing NR1 mRNA, the major N-methyl-D-aspartate receptor (NMDAR) subunit in the cells.

Interactions

Description

UniProt ID

Protein: Proteasome subunit beta type-5, Gene: PSMB5
Gene: GSK3B

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 526.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Amiloid
Anti Atherogenic
Anti Depressant
Anti Convulsant
Neuroprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

GSK3B

Experimental conditions

Agar nematode growth medium + streptomycin-resistant E. coli OP50-1 25,5oC

Life Extension

Mean LS (%)
10.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

10 mM

More info about experiment

24398558
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
0.0
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

More info about experiment

21301855
Opposite effectNo