Lamotrigine

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CAS: 84057-84-1

Name:

Lamotrigine

Other names:

Lamictal; Lamictal Cd; Lamotrigina; Lamotriginum; Labileno; Lamictin; Lamiktal; Lamictal XR; Crisomet

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating clinical depression.[1] For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, lamotrigine also seems to act as an effective mood stabilizer, and has been the first US Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type I. [Wikipedia]

Interactions

Description

UniProt ID

Protein: Aquaporin-4, Gene: AQP4
Protein: 5-hydroxytryptamine receptor 1A, Gene: HTR1A
Protein: Potassium voltage-gated channel subfamily H member 2, Gene: KCNH2
Protein: Solute carrier family 22 member 1, Gene: SLC22A1
Gene: SCN5A

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 185.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Amiloid
Anti Depressant
Anti Convulsant
Neuroprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
17.2
Median LS (%)
Mortality rate derease (%)
Max LS (%)
17.6
Cell CLS
Cell RLS

Concentration wth maximum effect

12 mg/ml

More info about experiment

19430925
Opposite effectNo