Kn-93
CAS: 139298-40-1
Name:
Kn-93
Other names:
kn-93; InSolution™ KN-93; KN93; 2-(N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
KN-93 is a methoxybenzenesulfonamide that is an effective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) phosphorylating activity, and the autophosphorylation of the α- and β-subunits of CaMKII. In PC-12h cells, KN-93 has been shown to decrease phosphorylation of KCl and acetylcholine. Data suggests that KN-93 modulates the reaction rate of TH by reducing the Ca2+ mediated phosphorylation levels of TH and inhibiting dopamine formation. In rat pancreatic beta cell studies, KN-93 was shown to block insulin release, and in prostrate cancer research, KN-93 inhibited androgen receptor function and enhanced cell death independent of p53 and Akt. Research indicates that KN-93 induces G1 cell cycle arrest in both HeLa (sc-2200) and NIH 3T3 fibroblast cells (sc-2210), and causes apoptosis in NIH 3T3 cells.
Interactions
Description
UniProt ID
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 20.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
10-100 mkM